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Search by company name (Bolden, Pax, OncoLux, Nabsys), asset id, or title. Each card links to a full dossier with cited evidence.

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Tier Bip_osteopearl_vcf_lenoss
Biological kyphoplasty / VCF — OsteoPearl cortical allograft & Elevoss cavity system

Cortical allograft kyphoplasty without PMMA—commercial early with Series A traction.

NEMIC + Commerce voucher—growth equity, not university OTL formation.

Entity: Lenoss MedicalPatents: 7Stage: commercial early us
Open dossier
Tier Bip_tregitope_immunomod
Tregitope regulatory T-cell epitope therapeutics

Deepest RI immunoinformatics patent cluster—platform ARR plus therapeutic spinouts.

Growth/strategic capital on Tregitope stack—not classic Slater seed formation.

Entity: EpiVaxPatents: 10Stage: platform commercial plus therapeutic
Open dossier
Tier Bip_biglycan_msk
Biglycan musculoskeletal & neuromuscular regeneration

BRF biglycan MSK regeneration—classic Brown OTL out-license with no RI startup mapped.

Preclinical academic package—physician KOL SAB + Slater seed after PoC.

Patents: 2Stage: preclinical academic
Open dossier
Tier Bip_neural_decoding_legacy
Core neural signal decoding & cortical interface (Donoghue era)

Foundational BMI decode patents—FTO diligence essential for new neurotech entrants.

Royalty or field-of-use license vs wireless/speech sub-families.

Entity: BrainGatePatents: 5Stage: clinical legacy
Open dossier
Tier Bip_af_mapping_ai
AI-guided atrial fibrillation ablation mapping (VX1)

FDA-cleared AI AF ablation mapping—growth-stage SaMD with protected claims.

~€74M VC path—strategic or growth round, not formation.

Entity: Volta MedicalPatents: 2Stage: fda cleared commercial
Open dossier
Tier Bip_oncolux_lumis
LUMIS optical theranostics — intraoperative see-and-treat oncology

See malignant margins and treat in the same OR workflow—AI-guided optical theranostics.

RILSH attraction award + Ocean State Labs + Mayo know-how—medtech growth, not university OTL.

Entity: OncoLuxPatents: 3Stage: clinical validation
Open dossier
Tier APatent gapgap_ni2o_kiwi_bci
KIWI wireless micro-implant BCI (ni2o)

KIWI wireless micro-implant BCI—Providence HQ with BrainGate FTO diligence.

Nurosene partnership + strategic path—harvest Howard/ni2o USPTO vs Brown patents.

Entity: ni2oPatents: 3Stage: preclinical grant
Open dossier
Tier APatent gapgap_smurf2_oncology
SMURF2–HIF1α oncology

HIF-pathway oncology with Welireg-scale commercial proof—harvest El-Deiry estate.

R01CA173453 + SMURF-Tx Providence—Slater seed after biomarker PoC.

Entity: SMURF-TherapeuticsPatents: 3Stage: preclinical grant
Open dossier
Tier APatent gapgap_soma_dtx
SOMA interoception / pain digital therapeutic

COBRE-backed interoception pain DTx—spinout forming from Carney.

Kaia-class financing vs Pear Ch.11 payer lesson—SaMD path after pivotal pilot.

Entity: SOMASciencePatents: Stage: preclinical grant
Open dossier
Tier APatent gapgap_christensen_epigenetics
HiTIMED / immune epigenetic deconvolution

HiTIMED immune epigenetic deconvolution—Dartmouth EP pending, Brown collaborator.

R01 stack + EP4505463A1—pharma license model, not classic biotech VC.

Patents: 3Stage: preclinical grant
Open dossier
Tier APatent gapgap_levine_pediatric_sepsis
Wearable pediatric sepsis ML (Levine / Garbern)

Wearable ML for earlier pediatric sepsis recognition—validated in Bangladesh ICU cohort.

FIC R33TW012211 → US SaMD path; pairs with RIH RNA Dx stack.

Patents: Stage: preclinical grant
Open dossier
Tier APatent gapgap_uri_phlip_lnp
PHLIP peptide–LNP nucleic acid & STING delivery (URI)

URI PHLIP delivers cargo into acidic tissues—LNP and STING programs without classic endocytosis.

URI tech transfer → RI spinout or license; Engelman/Reshetnyak PHLIP science (PMID 24659971).

Patents: 3Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_salivary_ev_ad
Salivary EV biomarkers for Alzheimer's disease (RIH)

Salivary extracellular vesicles as a non-invasive Alzheimer's liquid biopsy.

RIH/Brown R01AG074284 supports analytical development; path to CLIA LDT then spinout.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_bx912_pulmonary_htn
BX-912 for pulmonary hypertension (RIH)

BX-912 program for pulmonary hypertension—RIH PCT with multi-center inventor team.

Preclinical PH models → IND-enabling; benchmark against 2024 PAH biologic approval.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_pahtn_dx
PAH / sudden cardiac death diagnostics (RIH)

RIH diagnostic panel for pulmonary arterial hypertension and sudden cardiac death risk.

Mature US20180094317 family; retrospective → prospective validation.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_bbb_nucleic_delivery
BBB-crossing nucleic acid delivery (RIH)

RIH platform for nucleic acid delivery across the blood–brain barrier.

Qian Chen (NanoDe peer) leads BBB nucleic delivery PCT; partner or license path.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_motile_cell_msk
Motile injectable cell for MSK repair (RIH)

Motile injectable cell therapy to accelerate meniscus and connective-tissue repair.

NIAMS R01AR080726 + R21AR077326 (Jayasuriya); large-animal next gate.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_ecm_joint_repair
Biomimetic ECM for joint tissue repair (RIH)

Biomimetic ECM reconstitution for musculoskeletal joint repair.

Field-of-use diligence vs XM Therapeutics before Slater-scale spinout.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_enhancer_rna_glioma
Enhancer RNA targeting for primary brain tumors (RIH)

Enhancer RNA–targeted approach for primary brain tumors.

Tapinos-led RIH/Brown program; glioma model efficacy before neuro-onc seed.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_lpa_therapeutic
Lp(a)-lowering therapeutic approach (RIH)

RIH therapeutic approach to lower lipoprotein(a)—cardiovascular metabolic niche.

Differentiate vs Phase 3 siRNA/antisense leaders; Song lab R01HL159204 anchors cardio lipid biology.

Patents: 1Stage: preclinical grant
Open dossier
Research synthesis from public sources (NIH RePORTER, ClinicalTrials.gov, PubMed, USPTO, company press). Not investment advice, legal opinion, or clinical guidance. Verify cap tables, license chains, and trial status in data rooms before term sheets.