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Search by company name (Bolden, Pax, OncoLux, Nabsys), asset id, or title. Each card links to a full dossier with cited evidence.

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Tier Aip_wireless_neurograins
Wireless neurograins & distributed cortical implants

DARPA-scale wireless neurograins—dense cortical sensing without Utah-array tethers.

Brown OTL spinout after ~$19M DARPA + UH2—hardware path parallel to BrainGate decode IP.

Patents: 8Stage: preclinical human path
Open dossier
Tier Aip_speech_tablet_ibci
Speech decoding & multi-device tablet iBCI

Recruiting speech and tablet iBCI trials—decode IP distinct from electrode vendors.

U01 + VA funding with NCT05724173 family—consortium license or device co-development.

Entity: BrainGatePatents: 6Stage: clinical trials recruiting
Open dossier
Tier Aip_nanopieces_rna
Nanopieces non-viral RNA / nanocarrier delivery

Hospital-owned non-viral RNA nanocarriers—STTR-backed with expanded field-of-use option.

RIH assignee + R41TR002298—license to NanoDe or second newco beyond current scope.

Entity: NanoDe TherapeuticsPatents: 4Stage: preclinical sbir
Open dossier
Tier Aip_chitinase_ocf203
Chitinase-1 inhibition for pulmonary fibrosis (OCF-203 family)

Chitinase-1 IPF composition with decades of NHLBI P01 support—license diligence on OCF-203.

Brown-origin US11717528B2—sublicense or asset path via Ocean / Elkurt corporate stack.

Entity: Ocean BiomedicalPatents: 1Stage: preclinical to ind
Open dossier
Tier Aip_ecm_morsels_xm
Lab-grown decellularized ECM morsels (injectable matrix therapy)

Injectable human ECM morsels for HF and IPF—Slater-seeded Brown spinout.

Slater $375K + BBII—large-animal PoP before Heartseed-class Series A.

Entity: XM TherapeuticsPatents: 5Stage: preclinical proof of principle
Open dossier
Tier Aip_iaip_neonatal
IAIP biologics & rapid LFIA for sepsis/NEC/HIE

Dual-path NICU play—IAIP biologic plus rapid LFIA on active SBIR stack.

~$3.7M+ active SBIR—physician-founder equity; Series A $5–10M band vs Inotrem/MeMed.

Entity: ProThera BiologicsPatents: 4Stage: sbir clinical enabling
Open dossier
Tier Aip_dendritic_ad_mindimmune
Peripheral dendritic-cell blockade for Alzheimer's (MITI-101)

Block dendritic recruitment to AD brain—$30M Series A with RI Hub IND grant.

MITI-101 mAb post–Series A—co-invest or extension with Slater/RightHill in syndicate.

Entity: MindImmunePatents: 3Stage: preclinical ind enabling
Open dossier
Tier Aip_monaghan_deep_rna_dx
Deep RNA transcriptomic ICU diagnostics (host + pathogen)

One blood draw, full transcriptome—faster pathogen ID than culture, with host splicing biomarkers.

RIH-owned deep RNA platform + NIGMS R35 + Brown RNA Center—physician-founder spinout before national blood-RNA Dx scale-up.

Patents: 4Stage: clinical translational ldt
Open dossier
Tier Aip_spinal_isi_dbs
Intelligent spinal interface & closed-loop DBS facilitation

DARPA intelligent spinal interface—SCI rehab IDE distinct from cortical BCI.

DARPA $6.3M + NCT04302259—medtech strategic or SPV vs wireless neurograins.

Patents: 2Stage: early clinical ide
Open dossier
Tier Aip_pax_aav_vegf_tendon
AAV2–VEGF gene therapy for tendon & ligament repair (PAX-001)

One-shot gene therapy at repair—faster, stronger tendon healing than surgery alone.

RIH-origin patents + ~$1.7M seed + RILSH LIFT for IND—physician-chairman Liu MD with pre-IND complete.

Entity: Pax TherapeuticsPatents: 1Stage: preclinical ind enabling
Open dossier
Tier Aip_bolden_musk_neurogenesis
MuSK-pathway ASO neurogenesis (Bolden Therapeutics)

ASO switch for neural stem-cell quiescence—Brown Fallon/Webb science in a Slater-backed Providence newco.

NIA STTR + $1.5M pre-seed (Slater, Lifespan Vision)—formation capital before Big Pharma neurogenesis comparables.

Entity: Bolden TherapeuticsPatents: 3Stage: preclinical in vivo
Open dossier
Tier APatent gapgap_ni2o_kiwi_bci
KIWI wireless micro-implant BCI (ni2o)

KIWI wireless micro-implant BCI—Providence HQ with BrainGate FTO diligence.

Nurosene partnership + strategic path—harvest Howard/ni2o USPTO vs Brown patents.

Entity: ni2oPatents: 3Stage: preclinical grant
Open dossier
Tier APatent gapgap_smurf2_oncology
SMURF2–HIF1α oncology

HIF-pathway oncology with Welireg-scale commercial proof—harvest El-Deiry estate.

R01CA173453 + SMURF-Tx Providence—Slater seed after biomarker PoC.

Entity: SMURF-TherapeuticsPatents: 3Stage: preclinical grant
Open dossier
Tier APatent gapgap_soma_dtx
SOMA interoception / pain digital therapeutic

COBRE-backed interoception pain DTx—spinout forming from Carney.

Kaia-class financing vs Pear Ch.11 payer lesson—SaMD path after pivotal pilot.

Entity: SOMASciencePatents: Stage: preclinical grant
Open dossier
Tier APatent gapgap_christensen_epigenetics
HiTIMED / immune epigenetic deconvolution

HiTIMED immune epigenetic deconvolution—Dartmouth EP pending, Brown collaborator.

R01 stack + EP4505463A1—pharma license model, not classic biotech VC.

Patents: 3Stage: preclinical grant
Open dossier
Tier APatent gapgap_levine_pediatric_sepsis
Wearable pediatric sepsis ML (Levine / Garbern)

Wearable ML for earlier pediatric sepsis recognition—validated in Bangladesh ICU cohort.

FIC R33TW012211 → US SaMD path; pairs with RIH RNA Dx stack.

Patents: Stage: preclinical grant
Open dossier
Tier APatent gapgap_uri_phlip_lnp
PHLIP peptide–LNP nucleic acid & STING delivery (URI)

URI PHLIP delivers cargo into acidic tissues—LNP and STING programs without classic endocytosis.

URI tech transfer → RI spinout or license; Engelman/Reshetnyak PHLIP science (PMID 24659971).

Patents: 3Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_salivary_ev_ad
Salivary EV biomarkers for Alzheimer's disease (RIH)

Salivary extracellular vesicles as a non-invasive Alzheimer's liquid biopsy.

RIH/Brown R01AG074284 supports analytical development; path to CLIA LDT then spinout.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_bx912_pulmonary_htn
BX-912 for pulmonary hypertension (RIH)

BX-912 program for pulmonary hypertension—RIH PCT with multi-center inventor team.

Preclinical PH models → IND-enabling; benchmark against 2024 PAH biologic approval.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_pahtn_dx
PAH / sudden cardiac death diagnostics (RIH)

RIH diagnostic panel for pulmonary arterial hypertension and sudden cardiac death risk.

Mature US20180094317 family; retrospective → prospective validation.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_bbb_nucleic_delivery
BBB-crossing nucleic acid delivery (RIH)

RIH platform for nucleic acid delivery across the blood–brain barrier.

Qian Chen (NanoDe peer) leads BBB nucleic delivery PCT; partner or license path.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_motile_cell_msk
Motile injectable cell for MSK repair (RIH)

Motile injectable cell therapy to accelerate meniscus and connective-tissue repair.

NIAMS R01AR080726 + R21AR077326 (Jayasuriya); large-animal next gate.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_ecm_joint_repair
Biomimetic ECM for joint tissue repair (RIH)

Biomimetic ECM reconstitution for musculoskeletal joint repair.

Field-of-use diligence vs XM Therapeutics before Slater-scale spinout.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_enhancer_rna_glioma
Enhancer RNA targeting for primary brain tumors (RIH)

Enhancer RNA–targeted approach for primary brain tumors.

Tapinos-led RIH/Brown program; glioma model efficacy before neuro-onc seed.

Patents: 1Stage: preclinical grant
Open dossier
Tier APatent gapgap_rih_lpa_therapeutic
Lp(a)-lowering therapeutic approach (RIH)

RIH therapeutic approach to lower lipoprotein(a)—cardiovascular metabolic niche.

Differentiate vs Phase 3 siRNA/antisense leaders; Song lab R01HL159204 anchors cardio lipid biology.

Patents: 1Stage: preclinical grant
Open dossier
Research synthesis from public sources (NIH RePORTER, ClinicalTrials.gov, PubMed, USPTO, company press). Not investment advice, legal opinion, or clinical guidance. Verify cap tables, license chains, and trial status in data rooms before term sheets.