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Tier Bip_tregitope_immunomod
Tregitope regulatory T-cell epitope therapeutics

Deepest RI immunoinformatics patent cluster—platform ARR plus therapeutic spinouts.

Growth/strategic capital on Tregitope stack—not classic Slater seed formation.

Entity: EpiVaxPatents: 10Stage: platform commercial plus therapeutic
US7884184B2US10213496B2US11844826B2US10751397B2US10925939B2R43AI174486
Open dossier
Tier APatent gapgap_smurf2_oncology
SMURF2–HIF1α oncology

HIF-pathway oncology with Welireg-scale commercial proof—harvest El-Deiry estate.

R01CA173453 + SMURF-Tx Providence—Slater seed after biomarker PoC.

Entity: SMURF-TherapeuticsPatents: 3Stage: preclinical grant
WO2024192252A1US20230183356A1US20230219957A1R01CA173453PMID 39697237PMID 34611473
Open dossier
Tier APatent gapgap_christensen_epigenetics
HiTIMED / immune epigenetic deconvolution

HiTIMED immune epigenetic deconvolution—Dartmouth EP pending, Brown collaborator.

R01 stack + EP4505463A1—pharma license model, not classic biotech VC.

Patents: 3Stage: preclinical grant
EP4505463A1US20250372198A1WO2023196051A1R01CA253976R01CA216265P20GM104416
Open dossier
Tier APatent gapgap_uri_phlip_lnp
PHLIP peptide–LNP nucleic acid & STING delivery (URI)

URI PHLIP delivers cargo into acidic tissues—LNP and STING programs without classic endocytosis.

URI tech transfer → RI spinout or license; Engelman/Reshetnyak PHLIP science (PMID 24659971).

Patents: 3Stage: preclinical grant
WO2025171027A1WO2025081077A1WO2024040027A1R01GM073857SourcePMID 24659971
Open dossier
Tier APatent gapgap_rih_enhancer_rna_glioma
Enhancer RNA targeting for primary brain tumors (RIH)

Enhancer RNA–targeted approach for primary brain tumors.

Tapinos-led RIH/Brown program; glioma model efficacy before neuro-onc seed.

Patents: 1Stage: preclinical grant
US20230323349A1R21CA235415PMID 40068999
Open dossier
Research synthesis from public sources (NIH RePORTER, ClinicalTrials.gov, PubMed, USPTO, company press). Not investment advice, legal opinion, or clinical guidance. Verify cap tables, license chains, and trial status in data rooms before term sheets.