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Tier Bip_osteopearl_vcf_lenoss
Biological kyphoplasty / VCF — OsteoPearl cortical allograft & Elevoss cavity system

Cortical allograft kyphoplasty without PMMA—commercial early with Series A traction.

NEMIC + Commerce voucher—growth equity, not university OTL formation.

Entity: Lenoss MedicalPatents: 7Stage: commercial early us
US10993756B2US12029463B2USD1106456S1USD1106457S1US10219851B1US20250099150A1
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Tier Bip_biglycan_msk
Biglycan musculoskeletal & neuromuscular regeneration

BRF biglycan MSK regeneration—classic Brown OTL out-license with no RI startup mapped.

Preclinical academic package—physician KOL SAB + Slater seed after PoC.

Patents: 2Stage: preclinical academic
US8658596B2US20110183910A1R21AG073743R21NS112743
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Tier APatent gapgap_rih_motile_cell_msk
Motile injectable cell for MSK repair (RIH)

Motile injectable cell therapy to accelerate meniscus and connective-tissue repair.

NIAMS R01AR080726 + R21AR077326 (Jayasuriya); large-animal next gate.

Patents: 1Stage: preclinical grant
WO2025155768A1R01AR080726R21AR077326PMID 36312551PMID 39763468
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Tier APatent gapgap_rih_ecm_joint_repair
Biomimetic ECM for joint tissue repair (RIH)

Biomimetic ECM reconstitution for musculoskeletal joint repair.

Field-of-use diligence vs XM Therapeutics before Slater-scale spinout.

Patents: 1Stage: preclinical grant
US20240139376A1R01AR080726R21AR077326PMID 29542287
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Tier APatent gapgap_rih_lpa_therapeutic
Lp(a)-lowering therapeutic approach (RIH)

RIH therapeutic approach to lower lipoprotein(a)—cardiovascular metabolic niche.

Differentiate vs Phase 3 siRNA/antisense leaders; Song lab R01HL159204 anchors cardio lipid biology.

Patents: 1Stage: preclinical grant
WO2025245119A1R01HL159204
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Research synthesis from public sources (NIH RePORTER, ClinicalTrials.gov, PubMed, USPTO, company press). Not investment advice, legal opinion, or clinical guidance. Verify cap tables, license chains, and trial status in data rooms before term sheets.