Diligence memo framework

This structure is designed for investment committees and executive teams that need concise, auditable scientific decision support.

1) Thesis and decision question

• What exact decision is being made now?
• What must be true biologically and commercially?

2) Evidence summary

• Target biology and mechanism.
• Disease association strength and context.
• Druggability/tractability and development constraints.

3) Risk register

• Biological risk.
• Translational/clinical execution risk.
• Competitive and positioning risk.
• Adoption and reimbursement pathway risk.

4) Recommendation

• Primary recommendation (go, conditional go, hold).
• Conditions and milestones for reassessment.
• 90-day actions and ownership.

Related pages: For investors, Portfolio triage rubric, Contact.