Portfolio triage rubric

A practical scoring rubric for ranking programs when resources are constrained and strategic focus is required.

Scoring dimensions

• Evidence conviction (association quality, source breadth, reproducibility).
• Execution feasibility (modality fit, trial complexity, timeline realism).
• Commercial edge (differentiation, competitive pressure, narrative clarity).
• Strategic fit (portfolio coherence, capability alignment, opportunity cost).

Suggested output categories

• Tier 1: resource now
• Tier 2: monitor and de-risk
• Tier 3: deprioritise or partner

Operating guidance

• Re-score on a fixed cadence as evidence updates.
• Track score changes with rationale, not just rank changes.
• Keep one decision owner per program to avoid drift.

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