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Tier APatent gapgap_soma_dtx
SOMA interoception / pain digital therapeutic

COBRE-backed interoception pain DTx—spinout forming from Carney.

Kaia-class financing vs Pear Ch.11 payer lesson—SaMD path after pivotal pilot.

Entity: SOMASciencePatents: —Stage: preclinical grant
P20GM103645PMID 33378658
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Tier APatent gapgap_levine_pediatric_sepsis
Wearable pediatric sepsis ML (Levine / Garbern)

Wearable ML for earlier pediatric sepsis recognition—validated in Bangladesh ICU cohort.

FIC R33TW012211 → US SaMD path; pairs with RIH RNA Dx stack.

Patents: —Stage: preclinical grant
R33TW012211R01DK116163D43TW012768PMID 39475844PMID 41252746
Open dossier
Tier APatent gapgap_rih_salivary_ev_ad
Salivary EV biomarkers for Alzheimer's disease (RIH)

Salivary extracellular vesicles as a non-invasive Alzheimer's liquid biopsy.

RIH/Brown R01AG074284 supports analytical development; path to CLIA LDT then spinout.

Patents: 1Stage: preclinical grant
US20260103757A1R01AG074284PMID 41602168
Open dossier
Tier APatent gapgap_rih_bx912_pulmonary_htn
BX-912 for pulmonary hypertension (RIH)

BX-912 program for pulmonary hypertension—RIH PCT with multi-center inventor team.

Preclinical PH models → IND-enabling; benchmark against 2024 PAH biologic approval.

Patents: 1Stage: preclinical grant
WO2026112526A1R01HL174007
Open dossier
Tier APatent gapgap_rih_pahtn_dx
PAH / sudden cardiac death diagnostics (RIH)

RIH diagnostic panel for pulmonary arterial hypertension and sudden cardiac death risk.

Mature US20180094317 family; retrospective → prospective validation.

Patents: 1Stage: preclinical grant
US20180094317A1R01HL174007R01HL141268R01HL104025
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Research synthesis from public sources (NIH RePORTER, ClinicalTrials.gov, PubMed, USPTO, company press). Not investment advice, legal opinion, or clinical guidance. Verify cap tables, license chains, and trial status in data rooms before term sheets.